Alan Alda & Candice Bergen Discuss Not Being ‘Gooey’ or ‘Sentimental’ in Love Letters

first_imgAlan Alda and Candice Bergen have known each other for decades, but have never worked together—until now. They are starring on Broadway in A.R. Gurney’s Love Letters, a title that Alda admits is potentially a bit misleading. “In spite of the title,” he says, “it’s not gooey and sentimental. It’s very tough, sometimes. And very funny. And there are only one or two actual love letters in the play.” The two have celebrated successful careers on the big and small screen, but there’s something special about being on stage together with just a table and two chairs. “Everyone who does it does it for the love of the work,” says Bergen. Have a look below, and catch the pair in Love Letters at the Brooks Atkinson Theatre; the two have just recently extended their run through December 18! Stacey Keach and Diana Rigg will now play December 19 through January 9, 2015, followed by Anjelica Huston and Martin Sheen from January 10 through February 15. Love Letters Show Closed This production ended its run on Dec. 14, 2014 Related Shows View Commentslast_img read more

Scott Credit Union signs MLB sponsorship deal

first_imgThe $1 billion Scott Credit Union signed a sponsorship deal May 12 that includes the naming rights of an MVP deck at Busch Stadium, the home field of Major League Baseball’s St. Louis Cardinals.Financial terms of the three-year agreement were not disclosed by the Edwardsville, Ill.-based cooperative.The MVP Deck is a covered outdoor party deck in the stadium’s left center field. The deal also includes scoreboard advertisements, player appearances and a sponsorship of a Cardinals promotional giveaway night. continue reading » 1SHARESShareShareSharePrintMailGooglePinterestDiggRedditStumbleuponDeliciousBufferTumblrlast_img read more

Gautam Gambhir not prioritizing India- Bangladesh match over worrying environmental pollution in Delhi

first_imgAdvertisement lweaxtlNBA Finals | Brooklyn Vs0Wingsuit rodeo📽Sindre E3b( IG: @_aubreyfisher @imraino ) 624sWould you ever consider trying this?😱8ya1feCan your students do this? 🌚9zrRoller skating! Powered by Firework The former Indian cricketer, Gautam Gambhir is not prioritizing India- Bangladesh T20 match over worrying environmental pollution in Delhi. The pollution level in Delhi post Diwali becomes too high and it is serious problem to deal with. According to the former Indian cricketer, a cricket match is a very small issue in front of a big problem like environment pollution.Advertisement Gautam Gambhir has joined BJP after retiring from cricket. Now he is also a MP and certainly his views are getting affected with this position. BCCI scheduled the match at Arun Jaitley Stadium knowing the environmental pollution level in Delhi in this time of the year. According to Gautam Gambhir, BCCI should have thought of an alternative venue for this game where the players would feel comfortable to play.Advertisement The practice sessions of both the sides might be cancelled ahead of the match due to this condition. According to the former Indian cricketer, the state Government of Delhi should be more active in reducing the pollution level in Delhi. The central Government has always been very much serious about this. However, the pollution rate in this year is less than the previous years and Gambhir has thanked people of Delhi for this.Sourav Ganguly unhappy with the omission of Gill and Rahane from the ODI SquadAdvertisement Advertisementlast_img read more

ATP Synthase Shows Reason for ‘Slippage’

first_img(Visited 409 times, 1 visits today)FacebookTwitterPinterestSave分享0 The engine of life shows more engineering finesse with each new discovery.ATP synthase is surely one of the most amazing molecular machines we have reported on. Tiny but mighty, this rotary engine that runs on protons released from the food we eat is incredibly efficient, fast, and complicated. Being essential for all life, it challenges any kind of step-wise evolutionary origin. But for years, scientists wondered about a mismatch between its two halves.The motor consists of two parts, called F0 (which rotates powered by proton motive force), and F1 (where ATP is synthesized, yielding 3 ATP per revolution). The puzzling mismatch comes from the number of units in these two halves. Different species of ATP synthase have 8 to 17 “c subunits” in F0 (usually 10 to 12) that make up the carousel that rotates and turns the “gamma” central stalk, which acts like a camshaft connecting the two parts. The F1 part, though, has three pairs of two units. For every complete rotation of F0, with a corresponding rotation of the camshaft, three ATP are produced in F1. Why is there not a nice integer division between the two? How can 11 c subunits in F0 correspond to 3 ATP molecules in F1? Is there some slippage in the mechanism?ATP synthase is a rotary motor that generates 3 ATP per revolution.A new paper in Science Magazine sheds more light on this puzzle. In “Rotary substates of mitochondrial ATP synthase reveal the basis of flexible F1-Fo coupling,” Murphy et al. address the issue: “An enduring question is how the stoichiometrically mismatched c ring in Fo (composed of 8 to 17 c subunits) and the three-fold symmetric F1 head are efficiently coupled.” The paper summary announces a reason for this mismatch that makes ATP synthase appear more and more like a “well-oiled machine”—They solved high-resolution cryo–electron microscopy structures of the ATP synthase complex, extracting 13 rotational substates. This collection of structures revealed that the rotation of the Fo ring and central stalk is coupled with partial rotations of the F1 head. This flexibility may enable the head to better couple continuous rotation with discrete ATP synthesis events.In other words, there is a slight rotation of the F1 head that not only synchronizes the two halves, but may actually contribute to the motor’s productivity. For those who like jargon,We find that the F1 head rotates together with the central stalk and c ring through approximately 30°, or one c subunit, at the beginning of each 120° step. Flexible coupling of the F1 head to the Fo motor is mediated primarily by a hinge at the interdomain link of the oligomycin sensitivity–conferring protein (OSCP) subunit that joins the F1 head to the peripheral stalk. The extended two-helix bundle of the central stalk γ subunit interacts with the catch-loop region of one β subunit of the F1 head. The resulting mechanism of flexible coupling is likely to be conserved [i.e., unevolved] in other F1-Fo ATP synthases. Our results provide much-needed context to a wealth of published data indicating that OSCP is a hub of metabolic control in the cell.This is an elegant design. It basically provides an interface between disparate parts, like a human-engineered”universal mount” with a flexible connector that can work with different models. The authors summarize this as follows:In ATP synthases, the F1 catalytic head can accompany the rotor through a rotation of ~30° at the beginning of each ~120° step. This movement allows flexible coupling of F1 and Fo. The interdomain hinge of OSCP facilitates flexible coupling and makes this subunit an apposite [def. “suitable; well-adapted; pertinent; relevant; apt”] point for the regulation of ATP synthesis.In addition, the authors found a metal ion (probably Zn+2) that may be involved in translating the proton flow into a torque. That’s another mysterious aspect of ATP synthase: how does a flow of protons actually turn the F0 motor? It’s been hard to tell, because that part of the engine is embedded in the membrane. They conclude, “A conserved [unevolved] metal ion in the proton access channel may synchronize c-ring protonation with rotation.” This hypothesis may require additional research. It might also be illuminating to investigate the diversity c subunits between species, to see whether there are reasons for 8, 10, 12, or 17 subunits depending on the environment, or whether they are due to neutral mutations which the conserved “flexible coupling” is designed to accommodate.Needless to say, the authors did not mention “evolution” in the paper.ATP synthase is a molecular machine you can use to “wow” your friends. “Did you know that you are running on rotary engines?” In simple terms, describe this waterwheel-like action that runs a mechanism that snaps ATP together, making 3 ATP per revolution. Tell them it is one of the most efficient engines ever discovered, but add that it is on the order of billionths of a meter in size. Tell them the protons come from the food you just ate, and that quadrillions of these little engines are spinning at over 6,000 RPM inside you right now. It might lead to some lively discussions about origins.last_img read more

Don’t Make Selling More Difficult Than It Has to Be

first_imgSelling well isn’t easy. In fact, it’s getting tougher all of the time. The environment is more challenging, and much more is expected of us.There are countless charlatans out marketing the magic bullet that will allow you to produce better sales results faster and with less effort. But you know that the too-good-to-be-true remedies are just that. But there are some who are honest enough to tell you the truth about how to make selling simple (but not easy).Today, my good friend, Mike Weinberg, releases his new book: New Sales. Simplified. I was fortunate to have the opportunity to write the foreword to Mike’s book, and my name appears on the cover of the book. I wanted to write the foreword to this book because I strongly believe that this book will help salespeople improve their sales results and win new business.The heart of Mike’s book for me is three big ideas.The first is Mike’s insistence that you choose your targets thoughtfully—and that you continue to pursue them. Readers here will recognize this idea as something I call dream clients. You need to know which prospects you can create breath taking, jaw dropping, and earth shattering value for and pursue them. Mike’s approach will help you make that list and pursue them over the long haul.The second really big idea is the sales story. You have to know how to share your ability to create value. You have to know how to convey the value you create in a way that is compelling to your dream clients. Most of all, you need a consistent story. Mike’s book provides instructions on how to build and use your sales story.Finally, in an act of undaunted courage, Mike has the audacity to suggest that you need to pick up the telephone. He even goes so far as to suggest you develop a script! Then he provides you direction in doing so.These three pieces together solve a lot of sales problems. The right targets make selling simpler. A compelling ability to create value for those targets makes selling simpler. And a focused discipline pursuit of these targets, continually prospecting and opening opportunities makes selling simpler. But it’s not easy.Go and buy Mike’s book. Read it carefully, and follow Mike’s action plan. Selling still isn’t easy, but you don’t have to make it more difficult by avoiding what Mike teaches. Get the Free eBook! Learn how to sell without a sales manager. Download my free eBook! You need to make sales. You need help now. We’ve got you covered. This eBook will help you Seize Your Sales Destiny, with or without a manager. Download Nowlast_img read more

South West Queensland Victorious

first_imgSouth West Queensland have taken out the first Grand Final played at the X-Blades National Touch League today, defeating the South Queensland Sharks 2-1.The first half in the Women’s 35’s was a tight encounter, with both teams unable to score at all. The second half started better, with the Sharks scoring in the second minute, through Anna Fuiava.Just one minute later the game was all tied up with SWQ’s Karen Hegedus scoring. The Queensland derby continued to be close, with neither team being able to break the defence. SWQ did manage, however, in the 12th minute, through Anita Hagarty.That was the final score of the match, handing South West Queensland the first title of the 2009 NTL.Congratulations to the team.last_img read more

10 months agoMan Utd boss Solskjaer: De Gea save best I’ve ever seen

first_imgAbout the authorPaul VegasShare the loveHave your say Man Utd boss Solskjaer: De Gea save best I’ve ever seenby Paul Vegas10 months agoSend to a friendShare the loveManchester United boss Ole Gunnar Solskjaer hailed David de Gea’s wonder save for victory over Huddersfield.United won 3-1, though De Gea’s intervention came at a crucial moment.Solskjaer said, “The result was great. Obviously, you win the game and get three points. I think we started off slowly and maybe [it was] the whole occasion, we took one touch too many, we didn’t create too many chances early on but, after we got the first goal, I think we settled down, we passed it quicker. “There was a period just before half-time when you thought we would get the second here and it will be game over. In the second half, the first seven or eight minutes, I think we struggled then David’s save was the key moment for us. “You know every team, whatever game you are playing, if you are at home or away, they will get a chance because there is quality in all Premier League teams and that save must be one of the best I have seen – probably the best.” last_img read more

10 months agoPochettino declares he could stay with Spurs ‘for 20 years’

first_imgTagsTransfersAbout the authorPaul VegasShare the loveHave your say Pochettino declares he could stay with Spurs ‘for 20 years’by Paul Vegas10 months agoSend to a friendShare the loveTottenham boss Mauricio Pochettino has declared he could stay with the Londoners for 20 years.The 46-year-old Argentine has guided Spurs to fifth, third, second and third in his four completed league seasons since joining from Southampton in 2014.”I hope, or I wish to be here 20 years, and decide to leave or to finish my career here,” said Pochettino.”I am so focused here, and want to help the club to achieve what the club want to be in history.”He added: “It would be fantastic. I am so happy to be here. I am so happy to work in that pressure. Why not?” last_img read more

Majority Of Georgia Fans Say They’d Rather Have Nick Chubb Than Todd Gurley At Running Back

first_imgNick Chubb and Sony Michel celebrating after a football game.ATHENS, GA – SEPTEMBER 26: Running back Nick Chubb #27 of the Georgia Bulldogs celebrates with running back Sony Michel #1 at the conclusion of the game against the Southern University Jaguars on September 26, 2015 at Sanford Stadium in Athens, Georgia. The Georgia Bulldogs won 48-6. (Photo by Todd Kirkland/Getty Images)Matt Chernoff, a sports talk radio host in Atlanta, posed the following hypothetical question on Twitter this afternoon. Which player would you (Georgia fans) rather have: Todd Gurley or Nick Chubb? Georgia fans If you could have Chubb or Gurley this season, who do you want?— Matt Chernoff (@RealMattlanta) August 26, 2015Gurley, who starred in Athens, Ga., for three seasons, is now a St. Louis Ram. Chubb, meanwhile, burst onto the scene in Gurley’s absence in 2014, rushing for 1,547 yards and 14 touchdowns. The majority answer for Georgia fans: Chubb. As of 3:40 p.m. E.T., 19 people had responded to the tweet. The responses: 10 for Chubb and four for Gurley (the other five said stuff like “Churley” or “both”).Some of the responses: @RealMattlanta Chubb. Gurley has a bum knee and Chubb was just as good, if not better last year.— Georgia Native (@Georgia_Native) August 26, [email protected] Chubb all the way. #ChubbSmash— Amen…Go Dawgs (@Amen_GoDawgs) August 26, [email protected] Chubb because QB/WRs are question marks. Will need a back who can not only handle workload, but be more effective bc of it— Matt Berry (@MattBerry05) August 26, [email protected] Gurley, I still think he has more take it to the house speed— Kevin Bearden (@KKevin4268) August 26, 2015Who would you take, Georgia fans?last_img read more