Postdoctoral Associate – Zhang (67844)

first_imgStrong immunological background and run multi-parameter flowcytometry and analysis; the lab has a Aurora Cytek that can run upto 22 color-panel flow cytometry.Mouse models of cancer or experience of other mouse models; itis required that the candidate is comfortable working withanimals. Preferred Qualifications:experience with Cell signaling and molecular biologytechniques, such as RT-PCR, Cloning, site-directed mutagenesis,Western Blotting, IP or co-IP, CRISPR based gene editing etc.Familiarity with genomic or epigenomic analytical platformssuch as RNA-sequencing, ChIP-sequencing also a plus.Strong bioinformatics background or willing to learnbioinformatics is a plus, but not required. Execute experiments independently and contribute tocollaborative projects.Train and supervise junior staff and undergraduate.Participate rotating lab duties.Analyze and present data at local and national meetings. The Department of Pathology, Immunology and Laboratory Medicine isseeking candidates to be a Postdoctoral Associate in the laboratoryof Dr. Weizhou Zhang. The main focus of Dr. Zhang laboratory is tounderstand tumor immune microenvironment of several human cancersincluding but not limited to breast cancer and renal cancers. Ourultimate goals are to identify novel molecular targets that havelineage-specific functions within solid tumor microenvironment. Onefield of specific research focus is to identify molecules that arecritical for the survival/maintenance/suppressive functions ofhuman cancer regulatory T cells, and that the same molecules areimportant for cancer progression. We will develop noveltherapeutics to inhibit/degrade such important targets usingdifferent technologies. For example, we have two targets that canbe inhibited by antibodies due to their secreted or membrane-boundnature; and we have one cytoplasmic and one nuclear protein thatcan be degraded by Proteolysis-targeting chimera (PROTAC), both ofwhich are under patent filing and translational development. Incollaboration with several laboratories with complimentaryexpertise, we have established techniques involving those inmolecular biology, cancer biology, immunology and immunotherapy,medicinal chemistry and bioinformatics etc. for streamlining targetdiscovery/validation, drug design/chemical synthesis (for example,using the advanced PROTAC technology), tumor model validation andimmune landscaping, as well as preclinical assessment for efficacyetc. .The candidate will benefit from a highly collaborative and diverseenvironment at the University of Florida by conduct independent andcollaborative studies in a cancer and immunology lab focusing onboth basic and translational studies; acquire additional experiencein bioinformatics and cancer immunology. The successful candidatewill be involved in exciting projects to understand human cancerTregs and how to select target to inhibit these highly immunesuppressive cell type. They will be encouraged to participate atscientific meetings and apply for training grants;This position is 100% protected research activity includingperforming investigational studies utilizing animal models andpatient specimens; reading research articles; writing papers/grantsetc; learning required techniques.center_img Applicant must be a Ph.D. in Immunology or Cancer Biology, orrelated fields with proven track record of productivity in form ofpublication in reputable journals. Hands-on-experience inlaboratory research and good computer skills are required.Will have solid experience working with lab animals and expertisein at least one of the following techniques: Candidates should submit a curriculum vitae, and three letters ofrecommendation. The letters of reference should be sent directly toProf. Weizhou Zhang, [email protected] review will begin immediately and continue until theposition is filled.The final candidate will be required to provide an officialtranscript to the hiring department upon hire. A transcript willnot be considered “official” if a designation of “Issued toStudent” is visible. Degrees earned from an education institutionoutside of the United States are required to be evaluated by aprofessional credentialing service provider approved by NationalAssociation of Credential Evaluation Services (NACES), which can befound at http://www.naces.org/If an accommodation due to a disability is needed to apply for thisposition, please call 352-392-2477 or the Florida Relay System at800-955-8771 (TDD). Hiring is contingent upon eligibility to workin the US. Searches are conducted in accordance with Florida’sSunshine Law.#medicine=35The University of Florida is committed to non-discrimination withrespect to race, creed, color, religion, age, disability, sex,sexual orientation, gender identity and expression, marital status,national origin, political opinions or affiliations, geneticinformation and veteran status in all aspects of employmentincluding recruitment, hiring, promotions, transfers, discipline,terminations, wage and salary administration, benefits, andtraining.last_img read more